While still a boy, Abraham Lincoln loses his mother to a vampire's bite. He vows revenge, but fails in the attempt, narrowly escaping with his life. He is rescued by Henry (Dominic Cooper), a charismatic vampire hunter who instructs Abe in the fine art of dispatching bloodsuckers. Abe (Benjamin Walker) continues his fight against the undead well into adulthood and his presidency, making a last stand against the ultimate vampire foe (Rufus Sewell) on the eve of the Civil War's defining battle.

Two centuries after Dr. Frankenstein assembles and reanimates his creature, Adam (Aaron Eckhart) is still living. He becomes embroiled in a war between two immortal races: gargoyles, the traditional protectors of mankind, and evil demons. Since Adam is neither human nor demon, gargoyle Queen Leonore (Miranda Otto) and demon Prince Naberius (Bill Nighy) each want him for their own purposes. It is up to Adam to discover his inner humanity and the reason for his continued existence.

A suicidal actor (Siu-hou Chin) tries to kill himself in an apartment building inhabited by a vampire hunter, ghosts and other supernatural beings.